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Sickle-cell Anemia

YouTubeNikolay's Genetics Lessons

Sickle-cell Anemia

The mutation that results in the sickle-cell disease phenotype is Non-conservative missense mutation. This mutation occurs in the hemoglobin beta gene (HBB) on chromosome 11, where a single nucleotide substitution (adenine to thymine) leads to the replacement of the amino acid glutamic acid with valine at the sixth position of the beta-globin ...

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