When viruses invade a plant, you might expect an all-out immune war. But new research published in Science shows that, much like in humans, too strong an immune response can actually do more harm than ...

Halting the insidious accumulation of irreversible disability remains the principal challenge in multiple sclerosis care. Once classified as relapsing (including relapsing-remitting and active ...

Researchers found that lowering MHC I can expose cancerous or foreign cells to CD4+ T cell attack, reshaping assumptions ...

White blood cells called neutrophils act as factories for C4A, linking peripheral immunity to schizophrenia and synaptic ...

The complement system bridges innate and adaptive immunity, orchestrating immune surveillance and maintaining tissue homeostasis. This review summarizes the role of the complement system in ...

Managing complement 3 glomerulopathy involves several treatment options aimed at slowing disease progression and protecting kidney function. These may include blood pressure control, steroids, ...

Why does the same virus barely faze one person while sending another to the hospital? New research shows the answer lies in a molecular record etched into our immune cells by both our genes and our ...

The complement cascade is a vital component of the innate immune system. It consists of around 50 proteins, including circulating complement proteins and membrane-bound receptors. It operates through ...

The advent of mRNA vaccines against SARS-CoV-2 in 2020 changed the course of the COVID-19 pandemic. Now, the Nobel-prize–winning technology is being adapted to fight cancer, with mRNA vaccines in ...

Dozens of new discoveries reveal that defenses evolved by bacteria and viruses billions of years ago still define our own innate immune system. Evolutionary arms races — where one species is pitted ...

We sometimes hear about the benefits of “boosting” our immune system, but what we really want to do is support our immune system on an ongoing basis. People often think of the immune system as ...

Endometriosis is a painful, debilitating condition affecting 10% of women worldwide. It occurs when tissue similar to the lining of the uterus (known as lesions) grows elsewhere in the body — usually ...