GEN

Spatial Biology Moves Cancer Research Forward

Spatial biology is a rapidly advancing discipline that examines biological molecules (such as DNA, RNA, and proteins) within their native locations in tissues. This approach offers critical insight ...
IEEE

Sparser2Sparse: Single-shot Sparser-to-Sparse Learning for Spatial Transcriptomics Imputation with Natural Image Co-learning

Abstract: Spatial transcriptomics (ST) has revolutionized biomedical research by enabling high-resolution gene expression profiling within tissues. However, the high cost and scarcity of ...
Frontiers

Understanding heterogeneity in the pathogenesis and drug responses of ulcerative colitis through single-cell and spatial transcriptomics

Ulcerative colitis (UC) is driven by mucosal inflammation and epithelial injury. Single cell RNA sequencing (scRNA-seq) enables high resolution profiling of immune, stromal and epithelial compartments ...
PNAS

How spatial patterns can lead to less resilient ecosystems

Many models suggest that spatial dynamics, such as vegetation pattern formation, enhance ecosystem resilience. Yet, these predictions have limited empirical validation and rely on assumptions that ...
IEEE

Spatially Resolved Transcriptomics Data Clustering With Modality Conflict Modulation

Abstract: Spatial transcriptomics (ST) clustering identifies distinct spatial domains within tissues and elucidates cellular interactions. While this approach has advanced human understanding of ...