Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by ...

The replication fork is more than just a means for DNA duplication. It is connected to a checkpoint system that keeps the genome intact and prevents cancer.

Researchers at The University of Texas MD Anderson Cancer Center have developed a new imaging method, known as RF-SIRF, that ...

DNA repair mechanism: HELQ helicase remodels stalled replication forks into stable structures, preventing harmful mutations under replication stress. Advanced imaging tool: RF-SIRF maps reversed forks ...

Mouse ES cells present active origin firing and replication forks that progress slowly throughout S phase. These features are integral aspects of genome replication ensuring genome integrity in ES ...