Autoimmune diseases, including systemic lupus erythematosus (SLE), are more common in women than men, and scientists are still trying to figure out why. One reason may be related to the number of X ...

As I pointed out in a previous post, female mammals deal with the problem of having two X chromosomes (left) to the male’s one by randomly inactivating one of them in each cell. The effect is ...

Science has revealed some of the secrets of the X chromosome, but many remain. In humans, female cells contain two X chromosomes (XX) and male cells contain one (XY). In each female cell, one X ...

Researchers at Linköping University in Sweden made an unexpected discovery while investigating genetically unique women. Their insights advance our understanding of our most enigmatic chromosome, the ...

Schematic diagram illustrating the novel epigenetic pathway. The dual modification on histone variant H3.3 recruits CBX7, which brings the scaffold protein KAP1 to chromatin. KAP1 facilitates H3K9me3 ...

Conventional investigations of the genetic contributors to Alzheimer's disease (AD) risk and progression have ignored the role of the X-chromosome, primarily due to technical analysis limitations. To ...

A study reveals that mosaic loss of the X chromosome in blood cells may indicate reduced natural conception likelihood in ...