Even those who maintain that super-resolution microscopy is a powerful tool of biological discovery have admitted that it may have a bit of an image problem. For example, in a recent review, several ...

Using a tiny, spherical glass lens sandwiched between two brass plates, the 17th-century Dutch microscopist Antonie van Leeuwenhoek was the first to officially describe red blood cells and sperm cells ...

Overcoming the resolution limit in a light microscope of around half a wavelength of light (about 250 nanometers) is one of the most significant developments in optics. Due to the wave nature of light ...

Researchers have shown that consumer-grade 3D printers and low-cost materials can be used to produce multi-element optical components that enable super-resolution imaging, with each lens costing less ...

To unravel the complexities of biological phenomena, scientists have long relied on microscopy to visualize the intricate details of their specimens, including tissue architecture, cell morphology, ...

When single-molecule super-resolution microscopes were first commercialized some 15 years ago, they made headlines for their ability to resolve individual molecules and structures at the nanometer ...

A collection of protocols covering a variety of methods to achieve super resolution in microscopy to include structured illumination, single-molecule fluorescence and localization-based approaches.

Inside living cells, mitochondria divide, lysosomes travel, and synaptic vesicles pulse—all in three dimensions (3Ds) and constant motion. Capturing these events with clarity is vital not just for ...

Cell surface receptors, such as the G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK), play central roles signalling pathways. Due to their central role in regulating a wide range ...

A super-resolution microscopy technique offers an unparalleled glimpse into how monoclonal antibodies bind to their targets on cancer cells to induce cell death. “There is a power in seeing things,” ...