Technologies that allow the efficient chemical modification of proteins under mild conditions are widely sought after. Sortase-mediated peptide ligation provides a strategy for modifying the N or C ...

Sortase enzymes are critical cysteine transpeptidases that naturally anchor proteins to the cell walls of Gram-positive bacteria. Their inherent specificity for short peptide motifs, such as LPXTG, ...

Researchers at the U.S. Department of Energy's Argonne National Laboratory and the University of Chicago have determined the crystal structure of sortase B, an enzyme found in the bacteria that cause ...

What makes a “good” antibody these days? The research community has different criteria based on their uses. Using antibodies for therapeutics is clearly the most demanding application. Therapeutic ...

Tracking interactions between different types of cells in the body can offer clues to an organism’s development, reveal cellular functions, or track tissues’ responses to treatments. However, existing ...

Researchers at the U.S. Department of Energy's Argonne National Laboratory and the University of Chicago have determined the crystal structure of sortase B, an enzyme found in the bacteria that ...