RIKEN researchers have discovered how an enzyme modifies gene expression by targeting certain stretches of messenger RNA ...
Imagine trying to design a key for a lock that is constantly changing its shape. That is the exact challenge we face in ...
Different DNA Structures Nucleate the Folding of Proteins to form specific complexes that modulate the readout of ...
Fusion oncoproteins arise when a gene fuses with another gene and acquires new abilities. Such abilities can include the formation of biomolecular condensates, "droplets" of concentrated proteins, DNA ...
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Order from disordered proteins: Physics-based algorithm designs biomolecules with custom properties
In synthetic and structural biology, advances in artificial intelligence have led to an explosion of designing new proteins with specific functions, from antibodies to blood clotting agents, by using ...
In synthetic and structural biology, advances in artificial intelligence have led to an explosion of designing new proteins with specific functions, from antibodies to blood clotting agents, by using ...
Protein dynamics and intrinsic disorder represent a paradigm shift in our understanding of protein structure and function. Rather than depending solely on a single stable three‐dimensional structure, ...
Intrinsically disordered proteins (IDPs) do not attain a stable secondary or tertiary structure and rapidly change their ...
Intrinsically disordered proteins (IDPs) make up about 30 percent of our proteome. They are important to many fundamental aspects of biology and disrupted in disease. Since they lack a stable shape, ...
Researchers at Harvard and Northwestern have developed a machine learning method that can design intrinsically disordered proteins with custom properties, addressing nearly 30% of all human proteins ...
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