In a recent study published in the Proceedings of the National Academy of Sciences Journal, researchers examined the therapeutic effects of targeting integrins for treating Amyotrophic lateral ...
In a recent study posted to the medRxiv* pre-print server, a team of researchers demonstrated the inhibitory action of integrin/transforming growth factor beta 1 (TGF-β1) inhibitor GLPG0187 on severe ...
This year’s Lasker Basic Medical Research Award recognizes the contributions of Drs. Richard Hynes, Erkki Ruoslahti, and Timothy Springer for their discovery and characterization of integrins, a major ...
At last, the researchers have defined the molecular basis of the cell membrane in integrin activation. Scripps Research scientists have uncovered the workings of a critical process in cell survival.
Integrins are heterodimer transmembrane receptors for the extracellular matrix composed of an alpha and beta subunit. Natural integrin ligands include laminin, fibronectin, and vitronectin, but they ...
Protein evolution occurs slowly via small incremental mutations—usually. However, dramatic changes can happen: for instance, a fragment of one protein getting copied into the middle of another. While ...
Johns Hopkins University biologists have found that a protein that plays a key role in the lives of stem cells can bolster the growth of damaged muscle tissue, a step that could potentially contribute ...
Talin is a protein that plays an important role in the immune system by activating integrins, receptors that help cells attach to one another. Now a new study by Fox Chase Cancer Center researchers ...
The tissue in our body can only hold together if the cells adhere not only to each other, but also to extracellular structures, such as collagen fibers of the connective tissue and the skin. How ...
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