Strands of DNA wrapped around a histone. Credit: Molekuul/Science Source Histones are among the most abundant proteins in the body. They act as spools that help compact DNA so our enormous genomes ...

Post-traumatic osteoarthritis develops rapidly after joint injury, yet current treatments largely address symptoms rather ...

Histone modification is an epigenetic mechanism that enables fine-tuning of gene expression. Mutation or dysregulation of proteins associated with histone modification (called “writers,” “erasers,” ...

Histone modification is an epigenetic mechanism that regulates gene expression by altering chromatin structure and DNA accessibility for transcription. Histone modification is regulated by various ...

Cardiovascular disease remains the leading cause of mortality worldwide, necessitating deeper insights into its molecular underpinnings beyond genetic predisposition. Epigenetic modifications, ...

Post-traumatic osteoarthritis often affects younger, active individuals and progresses quickly following ligament or cartilage injury. Chondrocytes, the sole cell type in articular cartilage, survive ...

Modification of histone tails, by acetylation, methylation or phosphorylation, affects the local chromatin structure and the transcriptional regulation of adjacent genes. Pericentric heterochromatin ...

Molecular biologists decode the epigenetic silencing of problematic retroviral gene sequences. LMU molecular biologist Gunnar Schotta decodes the epigenetic silencing of problematic retroviral gene ...

Acetylation of histone H3 at the nucleosome surface is associated with destabilised nucleosomes and is a useful new functional genomics mark for identifying regulatory regions of the mammalian genome.

The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the next generation. Now, researchers from Kyushu University have demonstrated ...