Lipid nanoparticle-delivered messenger RNA encoding anti-PD-L1 nanobodies has reduced tumour growth in sporadic and colitis-associated colorectal cancer models, with quadruple constructs that ...

Can the weakened immune systems of older individuals be rejuvenated? Researchers from the German Cancer Research Center (DKFZ), the HI-STEM institute, and the Broad Institute have demonstrated that ...

Since addressing the COVID-19 pandemic, mRNA vaccines have risen as a promising tool for treating a broad range of diseases, such as cancer and genetic disorders. To be effective, foreign mRNA in ...

A team of researchers led by Dr. Kim V. Narry, director of the Center for RNA Research at the Institute for Basic Science (IBS), has uncovered a key cellular mechanism that affects the function of ...

Researchers developed an mRNA delivery system designed to improve embryo implantation. This approach could enhance ART outcomes and address uterine-factor infertility, with pre-clinical studies ...

The central dogma of molecular biology showing what is happening in this study. Credit: Julian Chen For the very first time, a study led by Julian Chen and his group in Arizona State University's ...

This study reports an important and novel finding that TENT5A, an enzyme involved in fine-tuning poly(A) tail length on selected mRNAs, is required for proper enamel mineralization in mice. The ...

Genome-wide CRISPR knockout screens to identify cellular regulators of LNP-based mRNA vaccines. mRNAs encoding Green Fluorescent Protein (GFP) were in vitro transcribed (IVT) and delivered to knockout ...

Moderna's new mRNA vaccine targets both flu and COVID-19, showing strong immune responses in trials, while non-celiac gluten sensitivity is linked to gut bacteria, as revealed by a study in mice.

Some genetic mutations that are expected to completely stop a gene from working surprisingly cause only mild or even no symptoms. Researchers in previous studies have discovered one reason why: cells ...