Nature

Network analysis of gene expression in peripheral blood identifies mTOR and NF-κB pathways involved in antipsychotic-induced extrapyramidal symptoms

Pharmacogenetics has been driven by a candidate gene approach. 4 The disadvantage of this approach is that the objects of study are circumscribed by our current understanding of the mechanisms by ...
Nature

Network analysis of gene expression in mice provides new evidence of involvement of the mTOR pathway in antipsychotic-induced extrapyramidal symptoms

Early acute extrapyramidal symptoms (EPS) are serious, debilitating and stigmatizing adverse effects of antipsychotics (AP). Although these side effects usually respond to dose reduction or to ...