Study reveals how an RNA enzyme drives the postnatal switch from glucose to fatty acids in heart cells, highlighting ketogenesis as essential for metabolism. Study: The tRNA methyltransferase Mettl1 ...

The amino acid side chains of proteins undergo various post-translational modifications (PTMs) which significantly impact protein function and mediate complex cellular events. Measuring the dynamics, ...

Post-translational modifications (PTMs)—the chemical changes that proteins undergo following biosynthesis—account for most protein forms, or proteoforms. Indeed, according to conservative estimates, ...

At the University of Oxford, scientists have developed a nanopore technology that can identify three different post-translational modifications (PTMs) in individual proteins, even deep within long ...

DOMEK is a multi-step pipeline which leverages mRNA display-derived next-generation sequencing data to derive kinetic information about substrates of post-translational modification enzymes.

When it comes to enzymes, protein abundance does not necessarily translate into protein activity: Post-translational modifications such as phosphorylation can dramatically alter enzyme function.

These variants are generated through a process known as post-translational modification (PTM), which occurs after a protein has been transcribed from DNA. PTM introduces structural changes such as the ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

Respiratory infections, pink eye, or an upset stomach may seem like unrelated, mild inconveniences, but all of these ailments share one root cause: adenovirus infection. Many of us will encounter some ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...