Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by ...

Genomic instability arises when the faithful duplication and transmission of DNA is compromised, leading to mutations, chromosomal rearrangements and copy number variations with broad implications for ...

Structural biologists at the University of Wisconsin-Madison today published cryo-electron microscopy structures of the complete bacterial DNA replication restart complex — a molecular machine that le ...

Researchers at The University of Texas MD Anderson Cancer Center have developed a new imaging method, known as RF-SIRF, that ...

Replication origins in Trypanosoma brucei integrate multiple features previously described individually in opisthokonts, revealing a unified structural topology built from strand-specific nucleotide ...

The first crystal structure of an alternative DNA shape from the insulin gene has been revealed. The first crystal structure of an alternative DNA shape from the insulin gene has been revealed by a ...

DNA repair mechanism: HELQ helicase remodels stalled replication forks into stable structures, preventing harmful mutations under replication stress. Advanced imaging tool: RF-SIRF maps reversed forks ...