A caffeine-triggered switch that turns CRISPR gene editing on and off inside cells could one day improve cancer therapy.

Cell and gene therapies (CGTs) represent the cutting edge of drug discovery. 1 These are amongst the most advanced medical treatments, specifically designed to correct the root genetic cause of an ...

CAR T cells are patient-derived, genetically engineered immune cells. They are "living drugs" and constitute a milestone in modern medicine. Equipping T cells, a key cell type of the immune system, ...

21 year old Sebastien Beauzile celebrates his Lyfgenia infusion with his medical team. Four months later, his doctors consider him cured from sickle cell anemia. A 21 year old man in New York has been ...

Cardiovascular disease remains the leading cause of mortality worldwide, necessitating deeper insights into its molecular ...

The Scottish Medicines Consortium (SMC) has accepted exagamglogene autotemcel (Casgevy, Vertex Pharmaceuticals) for use within NHS Scotland to treat sickle cell disease (SCD) in patients aged 12 years ...

Genetic defects are exceedingly common, which is not surprising considering just how many cells make up our bodies, including our reproductive cells. While most of these defects have no or only minor ...

A new study has uncovered how an exceptionally scarce protein can orchestrate the assembly of large‑scale gene-silencing structures inside cells, and ...