Lundbeck receives orphan drug designation in Japan for asedebart for the treatment of patients with congenital adrenal hyperplasia and Cushing's disease

Congenital adrenal hyperplasia (CAH) and Cushing's disease (CD) are rare disorders characterized by excess adrenocorticotropic hormone (ACTH) produced in the brain1,2; Current tre ...
Medscape

Want to Know What Caused Cushing? Urine Tests Can Help

Urinary free cortisol expressed as times above the upper limit of normal is a strong discriminator between ectopic ...
The New England Journal of Medicine

Cortisone and ACTH as an Adjunct to the Surgery of Craniopharyngiomas

THE surgical management of craniopharyngiomas, whether radical or conservative, has always been hazardous. Gordy, Peet and Kahn 1 reported a series of 51 cases in which the operative mortality was 41 ...
The New England Journal of Medicine

ACTH and Cortisone in Diseases of the Skin

MORE than 70 patients with cutaneous diseases have been treated at Massachusetts General Hospital, Peter Bent Brigham Hospital, Robert Breck Brigham Hospital and Children's Hospital with ACTH or ...
Medscape

Cortisol and the Polycystic Ovary Syndrome

Expert Rev Endocrinol Metab. 2012;7(5):555-566. To summarize, all available studies support the possibility that the HPA axis response to neuroendocrine stimuli may be altered only in a subset of ...
Nature

Sex Differences in the Ovine Fetal Cortisol Response to Stress

During threatening situations, the stress system coordinates adaptive responses that adjust homeostatic mechanisms to increase the individual's chance of survival. The hypothalamic-pituitary-adrenal ...